Wednesday, April 2, 2014

How to Think About the Risk of Autism - NYTimes.com

How to Think About the Risk of Autism - NYTimes.com: MANY known risks for autism occur during late pregnancy and birth. Premature birth is a risk for developmental disability, including autism. Notably, elective cesarean section is associated with an autism risk ratio of 1.9. Since a substantial proportion of early deliveries are elective, without a compelling medical reason, this risk is preventable.

A highly underappreciated prenatal risk is stress. For pregnant women who take the sometimes-wrenching step of emigrating to a new country, for example, the risk ratio is 2.3. In the fifth through ninth months of pregnancy, getting caught in a hurricane strike zone carries a risk ratio of about 3. Maternal post-traumatic stress disorder during pregnancy is associated with a similar effect. These events are likely to trigger the secretion of stress hormones, which can enter the fetus’s bloodstream and affect the developing brain for a lifetime. Stressors may also lead to maternal illness, the immune response to which may interfere with brain development.

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