Pantothenate kinase-associated neurodegeneration is not a synucleinopathy - Li - 2013 - Neuropathology and Applied Neurobiology - Wiley Online Library

Pantothenate kinase-associated neurodegeneration is not a synucleinopathy - Li - 2013 - Neuropathology and Applied Neurobiology - Wiley Online Library: Mutations in the pantothenate kinase 2 gene (PANK2) are responsible for the most common type of neurodegeneration with brain iron accumulation (NBIA), known as pantothenate kinase-associated neurodegeneration (PKAN). Historically, NBIA is considered a synucleinopathy with numerous reports of NBIA cases with Lewy bodies and Lewy neurites and some cases reporting additional abnormal tau accumulation. However, clinicopathological correlations in genetically proven PKAN cases are rare